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Objective:To study the relationship between the relevant chemical elements in the original surface drinking water sources and the prevalence of dental fluorosis in Bijie City, Guizhou Province, and to provide a scientific basis for further studying the distribution of dental fluorosis patients, clarifying the mechanism of endemic fluorosis, and scientifically adjusting relevant prevention and treatment policies.Methods:From August 2021 to March 2022, based on the local census data of endemic fluorosis in Guizhou Province, 385 samples of original surface drinking water sources were collected in 214 townships (towns) of Bijie City. The pH value, and contents of fluorine (F), calcium (Ca), magnesium (Mg), aluminum (Al), titanium (Ti), manganese (Mn), copper (Cu), zinc (Zn), nickel (Ni), arsenic (As), molybdenum (Mo), cadmium (Cd), barium (Ba), lead (Pb), chromium (Cr), iron (Fe), and selenium (Se) in the drinking water were determined. Taking the dental fluorosis index representing the prevalence of dental fluorosis as the dependent variable, a principal component multiple regression model was constructed based on the above chemical elements of drinking water to study the related factors affecting the prevalence of dental fluorosis, and its contribution rate was calculated.Results:The median of dental fluorosis index in 214 townships (towns) of Bijie City was 1.460. The average of pH values and contents of F, Ca, Mg, Al, Ti, Cr, Mn, Fe, Ni, Cu, Zn, As, Se, Mo, Cd, Ba and Pb of 385 drinking water samples were 6.369, and 0.209, 179.706, 16.198, 0.163, 0.987, 0.015, 0.073, 0.176, 0.027, 0.014, 0.191, 0.007, 0.005, 0.003, 0.001, 0.155, 0.005 mg/L, respectively. Six principal components ( F1 - F6) were extracted by principal component regression analysis, and the cumulative contribution rate was 72.05%. After multiple linear regression analysis, the chemical elements in drinking water were positively correlated with the prevalence of dental fluorosis in the order of Se, Fe, Cr, Mn, Ni, Cd and Cu, and negatively correlated with the prevalence of dental fluorosis in the order of Ba, F, Ti, Mo, Zn, Al, Pb, Ca, As and Mg. Conclusions:The chemical properties in drinking water of endemic fluorosis areas in Bijie City have obvious synergistic or antagonistic effects on the occurrence and prevalence of dental fluorosis in this area. The F in the drinking water may not play a decisive role in the occurrence and prevalence of local dental fluorosis.
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ObjectiveTo explore the effect of flipped classroom mode in the clinical probation teaching for undergraduate mental health students， so as to expand the new mode of clinical teaching in psychiatry department. MethodsA total of 85 undergraduate psychiatric students from Xinxiang Medical University in 2016 were selected. All participants were divided into experimental group （n=43） and control group （n=42） according to the random number table method. The flipped classroom clinical teaching mode was adopted to experimental group， and the traditional practice mode for control group. The probation lasted for 12 weeks. Theoretical knowledge of symptomology， psychiatric clinical skills （OSCE）， doctor-patient communication ability（SEGUE） and clinical thinking ability were assessed at the end of probation. ResultsAfter the probation， students in experimental group obtained higher scores in theoretical knowledge， clinical skills， doctor-patient communication ability and clinical thinking ability compared with control group. The differences were statistically significant ［（33.08±1.72） vs. （32.06±2.33）， （51.61±2.12） vs. （48.32±2.86）， （18.14±1.98） vs. （14.62±2.15）， （91.26±14.13） vs. （82.40±10.89）， t=2.307， 6.034， 3.230， 7.846， P<0.05 or 0.01］. ConclusionApplying the flipped classroom mode into the clinical probation teaching for mental health undergraduate students may help to improve students' theoretical knowledge level and clinical operation ability， faciliate doctor-patient communication， and have a positive impact on their clinical thinking ability.
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Background The pollution of agricultural products and the health risks caused by metals have become a hot spot of social concern. As China's main economic agricultural products, peppers are essential for health risk assessment. Objective By exploring the enrichment of common metals in different varieties of peppers in major growing areas of China, a bioavailability-based approach is used to assess dietary health risks of common metals in groups with different characteristics. Methods Through random sampling method, dried pepper samples from major pepper growing areas of China were purchased from the market, and were divided into Hippophae, Capsicum annuum, Magnoliopsida, Capsicum frutescens var, and Capsicum by morphological taxonomy, and a total of 667 batches of peppers were collected. Six common metals arsenic (As), cadmium (Cd), lead (Pb), nickel (Ni), copper (Cu), and zinc (Zn) were evaluated; physiologically based extraction test was designed to estimate the bioavailability of the metals in peppers and their associated dietary health risks were assessed. Results The concentrations of metals Cd and Ni in pepper exceeded the limits of China, and the disqualification rates were 6.1% and 22.7% respectively. The other metals were within the safe range; there were differences in the concentrations of As, Cd, Pb, Cu, and Zn among different pepper varieties (P<0.05). The order of bioavailability of the six metals in pepper from high to low was As (57.9%)>Cd (43.07%)>Zn (42.74%)>Pb (38.04%)>Ni (31.97%)>Cu (31.4%). Based on bioavailability, when the metal concentration in pepper was at the median level, the order of hazard quotient of metals in pepper was Cu>Cd>As>Ni>Zn>Pb, and at the 90th quantile level, the order was Cd>As>Cu>Ni>Zn>Pb; the hazard quotient of single metal element and the total target hazard quotient of combined metal elements were both less than 1, and these indicators of adults were higher than those of children. Conclusion In the collected pepper samples, the non-carcinogenic health risks of single metal elements and multiple metal elements are in the safe range. Based on gastrointestinal bioavailability, the dietary health risk of pepper is further reduced.
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Objective:We aimed to explore a colorectal cancer risk prediction model through machine learning algorithm based on the big data in laboratory medicine.Methods:According to the labeling of colonoscopy combined with pathology or referring to the ICD-10 code, the colonoscopy patients in Shanghai Changhai Hospital from 2013.1.1 to 2019.6.30 and the outpatients and inpatients from 2010.1.1 to 2019.6.30 were divided into colorectal cancer groups and non-colorectal cancer group. Four machine learning algorithms, Extreme gradient boosting(Xgboost),Artificial Neural Network(ANN),Support Vector Machine(SVM),Random Forest(RF), are used to mine all routine laboratory test item data of the enrolled patients, select model features and establish a classification model for colorectal cancer. And the effectiveness of the model was prospectively verified in patients in the whole hospital of Changhai Hospital from 2019.7.1 to 2020.8.31.Result:A colorectal cancer risk prediction model (CRC-Lab7) including 7 characteristics of fecal occult blood, carcinoembryonic antigen, red blood cell distribution width, lymphocyte count, albumin/globulin, high-density lipoprotein cholesterol and hepatitis B virus core antibody was constructed by the XgBoost algorithm. The AUC of the model in the validation set and prospective validation set were 0.799 and 0.816, respectively, which was significantly higher than that of fecal occult blood (AUC was 0.68 and 0.706, respectively). It also has high diagnostic accuracy for colorectal cancer with negative fecal occult blood or under 50 years old.Conclusion:In this study, a colorectal cancer risk prediction model was established by mining routine laboratory big data. The model′s performance is better than fecal occult blood, and it has high diagnostic accuracy for colorectal cancer in patients with negative fecal occult blood and younger than 50 years old.
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OBJECTIVE：To comp are the meridian tropism of compatible herbs and compatibility rules of ancient and modern prescriptions containing Eucommia ulmoides ，and to provide theoretical basis for modern clinical application of E. ulmoides . METHODS：Ancient prescriptions containing E. ulmoides were screened from Dictionary of TCM Prescription . The prescriptions containing E. ulmoides were screened from clinical trials which published in CNKI ，Wanfang database and VIP during Jan. 2000 to Jan. 2020. Data mining methods such as frequency statistics and Apriori algorithm were used to analyze the main diseases of ancient and modern prescriptions containing E. ulmoides and the use frequency ，types，meridian tropism and compatibility rules of medical materials. RESULTS ：A total of 84 ancient prescriptions and 188 modern prescriptions of E. ulmoides were included. Ancient prescriptions were mainly used to treat diseases such as back pain ，deficiency，threatened abortion. Modern prescriptions were mainly used to treat osteoarthropathy （mainly lumbar intervertebral disc herniation ），gynecological diseases ，cardiovascular diseases. Cinnamomum cassia ，Angelica sinensis and Achyranthes bidentatawerethe were the high-frequency compatible herbs in ancient prescriptions with E. ulmoides ，and were tonifying medicine ，dispelling wind and dampness medicine and clearing heat medicine；compatible herbs were mainly of warm property ，and the channel tropism was mostly kidney meridian and liver meridian；the five tastes of compatible herbs were mainly sweet and spicy. A. sinensis ，Glycyrrhiza uralensis and Rehmanniae Radix Praeparata were the high-frequency compatible herbs in modern prescriptions with E. ulmoides ，and were mainly tonic medicine，anti-rheumatic medicine ，medicine for promoting blood circulation and removing blood stasis ；compatible herbs were mainly of warm property ，and the channel tropism was mostly liver meridian and kidney meridian ；the five tastes of medicine were mainly bitter and spicy. By analyzing the Apriori association rules of high-frequency herbs ，a total of 10 core herbs combinations were obtained in ancient prescriptions ，including 8 third-order association rules and 2 fourth-order association rules ；a total of 11 core herbs combinations were obtained in modern prescriptions ，including 3 third-order association rules and 8 fourth-order association rules. CONCLUSIONS ： Ancient and modern prescriptions containing E. ulmoides are mainly used to treatlumbar disease ， followed by obstetrics and gynecology com diseases. In addition ，the modern prescriptions can also be #used for the treatment of cardiovascular and cerebrovascular diseases. The ancient prescriptions mainly focus on warming and tonifying ，while the modern prescriptions are more compatible with medicine for dispelling wind and dampness and medicine for promoting blood circulation and removing blood stasis on the basis of tonifying deficiency ；most of the medicines in ancient prescriptions contribute in kidney and liver meridians ，mainly sweet and pungent ，while most of the medicines in modern prescriptions contribute in liver meridian ，and are more compatible with bitter medicines.
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Objective:To explore the external factors of the development of cancer hospitals under normalized epidemic prevention and control, and to propose targeted strategies in accordance with existing practice.Methods:PEST model was used to analyze the political, economic, social and technological environment of specialized cancer hospitals, with an overall strategy proposed based on the specific analysis of a cancer hospital.Results:In the era of normalized epidemic prevention and control, cancer hospitals were facing a new environment that was common or unique to other types of medical institutions. In response, the case hospital had adopted such strategies as integrating prevention and control with medical services, integrating offline with online services, and integrating internal and external resources to promote its recovery and development.Conclusions:Cancer hospitals and government should fully leverage the environmental changes incurred by the normalization of prevention and control, and formulate a more integrated development strategy covering short, medium up to long term conditions, based on the two major objectives of epidemic prevention and control and cancer prevention and medical services.
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Value-based healthcare emphasizes the importance of taking patients′ needs and experiences into full consideration during the entire diagnosis and treatment process and providing patient-centered medical services, so as to improve population health and medical outcomes with manageable medical costs.From this perspective, it is particularly important to investigate how patients could take full advantage of their subjective value and central role to engage in healthcare-related activities. This article aims to summarize the concepts and specific pathways relevant to patient engagement in the entire healthcare process, and provide specific suggestions and recommendations on promoting participation in health self-monitoring, access to disease and consultation information, shared decision-making(SDM)between doctors and patients, patients for patient safety(PFPS), patient-reported outcomes(PROs), participation in self-management, and participation in patient organizations, etc. This article provided valuable reference and evidence on implementation of relevant medical practices and policies.
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Objective@#To explore the value of preventive nursing in the treatment of neonatal respiratory distress syndrome (NRDS) mechanical ventilation in premature infants.@*Methods@#A total of 45 NRDS preterm infants who received treatment during the preventive care program from February 1, 2018 to November 1, 2018 were selected as group A, 45 cases of NRDS preterm infants who received treatment during the preventive care program from January 1, 2017 to January 10, 2018 were included in group B for retrospective study. Baseline data, mechanical ventilation index, complications, and family satisfaction of the children were observed.@*Results@#The number of pulmonary surfactant applications, mechanical ventilation time, hospitalization time and hospitalization cost were (1.5±0.5) times, (92.5±13.8) h, (12.5±1.3) d, (26±4) thousand yuan in group A, and (2.6±0.4) times, (131.4±23.1) h, (16.0±2.8) d, (33±5) thousand yuan in group B, the highest oxygen saturation value was 468.9±42.1 in group A,401.2±22.3 in group B, there were significant difference between the two groups(t=7.334-11.524, P<0.05). The total incidence of complications during treatment was 15.6%(7/45) in group A and 48.9%(22/45), there was significant difference between the two groups (χ2=11.447, P<0.05). The total satisfaction rate of family members was 95.6%(43/45) in group A, which was significantly higher than that in group B (64.4%, 29/45). The difference was statistically significant (χ2=13.611, P<0.05).@*Conclusions@#Prophylactic care can be used in the mechanical ventilation of premature infants with NRDS, which can significantly reduce the incidence of complications, reduce the amount of pulmonary surfactant, shorten the mechanical ventilation time, and save the cost of treatment. It is worth promoting.
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Objective@#To study the effect of continuous nursing care on quality of life in patients with rheumatoid arthritis after discharge.@*Methods@#Patients with rheumatoid arthritis who were admitted to hospital from August 2016 to August 2017 were selected as the study subjects. According to the random number table method, they were divided into the control group and the research group, and the lost cases were eliminated. There were 99 cases in the control group and 94 cases in the research group. The control group was given routine care, and the research group conducted continuous nursing care measures on the basis of the control group. The morning stiffness time, pain score, disease activity, patient health status and nursing satisfaction of the two groups were observed before and 6 weeks after discharge.@*Results@#Six weeks after discharge, the morning stiffness time (23.76±12.76) min of the research group was significantly higher than that of the control group (38.22±14.53) min, the difference was statistically significant (t=3.865, P<0.05). Six weeks after discharge, the VAS (2.01±0.68) and HAQ (0.42±0.34) points of the research group were lower than those of the control group (4.17±1.30), (0.92±0.63) points, the difference was statistically significant (t=4.073, 3.916, P<0.05). The nursing satisfaction of the research group was 94.68%(89/94), and that of the control group was 78.79%(78/99), and the difference was statistically significant (χ2=9.416, P < 0.05).@*Conclusions@#The implementation of continuous care mode after discharge from patients with rheumatoid arthritis is beneficial to alleviate clinical symptoms such as morning stiffness and pain. Moreover, it can also improve patient health and quality of life, increase risk of disease progression, and care satisfaction is high which can help to protect the harmony between nurses and patients.
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Objective@#To analyze the risk factors of high-risk pregnancy, the change factor conversion rate and pregnancy outcomes, summarize the experience of high-risk pregnancy management, make it rationalized and standardized, improve the health of pregnant women and perinatal children, and guarantee the safety of mother and baby.@*Methods@#The 6 472 pregnant women who were admitted to the hospital from January 2016 to March 2017 were screened for high-risk factors according to the relevant management methods and implementation rules of high-risk pregnancies, and systematic management of high-risk pregnant women was conducted.@*Results@#Among 6 472 pregnant women, 1 610 pregnant women were high-risk pregnancies, and the incidence rate was 24.88%. Three or more high-risk factors accounted for 163 cases (10.12%), two high risk factors accounted for 391 (24.29%) , one risk factors accounted for 1056 cases (65.59%). The top five risk factors were abortion history, age, gestationathe or mild pre-eclampsia, preterm prematurity, and premature rupture of fetal membranes at more than 34 weeks. Among pregnant women with high risk, 249 cases (11.29%) were between 19 and 25 years old; 441 cases (18.27%) of 26-30 years old; 536 cases (36.49%) of 31-34 years old; 384 cases (100.00%) of the 35-year old. The incidence of high-risk pregnancy was closely related to age, and the incidence of high-risk pregnancy was 100% in patients over 35 years old, with the increase of age. The risk factors of hypertension, preterm birth, endocrine disease and prenatal hemorrhage could be change normal rates were 32.77% (58/177), 83.21% (109/131), 46.88% (45/96) and 83.13% (69/83) respectively. The age group with the highest cesarean section rate was ≥35 years old. The c-section rate gradually decreased with age. The age group with the highest vaginal assist rate was 31-34 years old high-risk pregnant women without obviously differences between groups; the highest perinatal mortality rate was ≥35 years old (P <0.05). The risk of eclampsia, puerperal infection and postpartum hemorrhage was significantly higher in maternal ≥35 years old than in other age groups (P <0.05).@*Conclusions@#There are many influencing factors of high risk pregnancy, screening, identification and management of the influence factors, attention to health education, to promote the hospital management and community management cooperation, strengthen the management of high-risk pregnancies, helps to reduce the risk of maternal severe adverse pregnancy outcomes, and improve maternal and infant prognosis.
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Objective To explore the value of preventive nursing in the treatment of neonatal respiratory distress syndrome (NRDS) mechanical ventilation in premature infants. Methods A total of 45 NRDS preterm infants who received treatment during the preventive care program from February 1, 2018 to November 1, 2018 were selected as group A, 45 cases of NRDS preterm infants who received treatment during the preventive care program from January 1, 2017 to January 10, 2018 were included in group B for retrospective study. Baseline data, mechanical ventilation index, complications, and family satisfaction of the children were observed. Results The number of pulmonary surfactant applications, mechanical ventilation time, hospitalization time and hospitalization cost were (1.5±0.5) times, (92.5±13.8) h, (12.5±1.3) d, (26±4) thousand yuan in group A, and (2.6±0.4) times, (131.4±23.1) h, (16.0±2.8) d, (33± 5) thousand yuan in group B, the highest oxygen saturation value was 468.9±42.1 in group A,401.2±22.3 in group B, there were significant difference between the two groups( t=7.334-11.524, P<0.05). The total incidence of complications during treatment was 15.6% (7/45) in group A and 48.9% (22/45) , there was significant difference between the two groups (χ2=11.447, P<0.05). The total satisfaction rate of family members was 95.6%(43/45) in group A, which was significantly higher than that in group B (64.4%, 29/45). The difference was statistically significant (χ2=13.611, P<0.05). Conclusions Prophylactic care can be used in the mechanical ventilation of premature infants with NRDS, which can significantly reduce the incidence of complications, reduce the amount of pulmonary surfactant, shorten the mechanical ventilation time, and save the cost of treatment. It is worth promoting.
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Objective To study the effect of continuous nursing care on quality of life in patients with rheumatoid arthritis after discharge. Methods Patients with rheumatoid arthritis who were admitted to hospital from August 2016 to August 2017 were selected as the study subjects. According to the random number table method, they were divided into the control group and the research group, and the lost cases were eliminated. There were 99 cases in the control group and 94 cases in the research group. The control group was given routine care, and the research group conducted continuous nursing care measures on the basis of the control group. The morning stiffness time, pain score, disease activity, patient health status and nursing satisfaction of the two groups were observed before and 6 weeks after discharge. Results Six weeks after discharge, the morning stiffness time (23.76 ± 12.76) min of the research group was significantly higher than that of the control group (38.22 ± 14.53) min, the difference was statistically significant (t =3.865, P<0.05). Six weeks after discharge, the VAS (2.01 ± 0.68) and HAQ (0.42 ± 0.34) points of the research group were lower than those of the control group (4.17±1.30), (0.92±0.63) points, the difference was statistically significant (t =4.073, 3.916, P<0.05). The nursing satisfaction of the research group was 94.68%(89/94), and that of the control group was 78.79%(78/99), and the difference was statistically significant (χ2=9.416, P<0.05). Conclusions The implementation of continuous care mode after discharge from patients with rheumatoid arthritis is beneficial to alleviate clinical symptoms such as morning stiffness and pain. Moreover, it can also improve patient health and quality of life, increase risk of disease progression, and care satisfaction is high which can help to protect the harmony between nurses and patients.
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Objective To analyze the risk factors of high-risk pregnancy, the change factor conversion rate and pregnancy outcomes, summarize the experience of high-risk pregnancy management, make it rationalized and standardized, improve the health of pregnant women and perinatal children, and guarantee the safety of mother and baby. Methods The 6 472 pregnant women who were admitted to the hospital from January 2016 to March 2017 were screened for high-risk factors according to the relevant management methods and implementation rules of high-risk pregnancies, and systematic management of high-risk pregnant women was conducted. Results Among 6 472 pregnant women, 1 610 pregnant women were high-risk pregnancies, and the incidence rate was 24.88%. Three or more high-risk factors accounted for 163 cases (10.12% ), two high risk factors accounted for 391(24.29%), one risk factors accounted for 1056 cases (65.59%). The top five risk factors were abortion history, age, gestationathe or mild pre-eclampsia, preterm prematurity, and premature rupture of fetal membranes at more than 34 weeks. Among pregnant women with high risk, 249 cases (11.29%) were between 19 and 25 years old; 441 cases (18.27%) of 26-30 years old; 536 cases (36.49%) of 31-34 years old; 384 cases (100.00%) of the 35-year old. The incidence of high-risk pregnancy was closely related to age, and the incidence of high-risk pregnancy was 100% in patients over 35 years old, with the increase of age. The risk factors of hypertension, preterm birth, endocrine disease and prenatal hemorrhage could be change normal rates were 32.77% (58/177), 83.21% (109/131), 46.88% (45/96) and 83.13% (69/83) respectively. The age group with the highest cesarean section rate was ≥35 years old. The c-section rate gradually decreased with age. The age group with the highest vaginal assist rate was 31-34 years old high-risk pregnant women without obviously differences between groups; the highest perinatal mortality rate was≥35 years old (P<0.05). The risk of eclampsia, puerperal infection and postpartum hemorrhage was significantly higher in maternal ≥35 years old than in other age groups (P <0.05). Conclusions There are many influencing factors of high risk pregnancy, screening, identification and management of the influence factors, attention to health education, to promote the hospital management and community management cooperation, strengthen the management of high-risk pregnancies, helps to reduce the risk of maternal severe adverse pregnancy outcomes, and improve maternal and infant prognosis.
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Pharmaceutical cocrystals are a promising technology that can be used to improve the solubility of poor aqueous compounds. The objective of this study was to systematically investigate the solubility of myricetin (MYR) cocrystals, including their kinetic solubility, thermodynamic solubility, and intrinsic dissolution rate (IDR). The effects of pH, surfactant, ion concentration, and coformers on the cocrystal solubility were evaluated. Furthermore, single crystal structures of MYR, myricetin-isonicotinamide (MYR-INM) and myricetin-caffeine (MYR-CAF) cocrystals were analyzed to discuss the possible reasons for the enhancement of cocrystal solubility from the perspective of the spatial structure. The results indicated that the kinetic solubility of MYR cocrystals was modulated by pH and cocrystal coformer (CCF) ionization in buffer solution, while it primarily depended on the CCF solubility in pure water. In addition, the solubility of MYR cocrystals was increased in a concentration dependent fashion by the surfactant or ion concentration. The thermodynamic solubility of MYR-INM (1:3) cocrystals decreased with the increases of the pH value of the dissolution media. The IDR of MYR cocrystals was faster than that of MYR in the same medium and extremely fast in pH 4.5 buffer. The improved solubility of MYR cocrystals was probably related to the alternate arrangements of MYR and INM/CAF molecules and increased intermolecular distance. The present study provides some references to investigate the solubility behavior of pharmaceutical cocrystals.
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The study is to establish the administrative ward round system and its effect evaluation system under the modern hospital management conditions, and explore the formation of a standardized, scientific and replicable standard mode of Administrative Ward round. According to the annual ward rounds plan, clinical departments and administrative departments were organized to decide the major issues of a department according to the procedures of " hearing-evaluation-discussion-decision " , and to ensure the implementation of management. Since 2016, administrative ward round has been carried out in 9 departments, and the medical quality and operational efficiency have been improved significantly. The closed-loop administrative ward rounds mode can effectively promote the modernization of hospital management system through the joint decision-making of clinical departments and functional departments.
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Objectives: The purpose of this study is to understand the relationships among plasma glucose, blood pressure level and Traditional Chinese Medicine (TCM) syndromes in Shanghai community residents, and provide a theoretical basis for the prevention of community chronic disease based on TCM syndrome differentiation.Methods: Residents above35 years old will attend the Type 2 Diabetes Mellitus (T2 DM) risk assessment at Community Health Center. By distributing questionnaires and performing glucose testing, we screened the residents at high risk of T2 DM, and conducted a physical examination of them. Further, a body constitution questionnaire was required to be completed by the residents. Results: In total, 933 residents were screened. The plasma glucose and blood pressure levels related to age, waist circumference, hip circumference, body mass index (BMI) and waist-to-height ratio (WHtR) . Residents with increasing blood pressure have an increased risk of T2 DM (P ＜ 0.01) . Total 529 questionnaires were completed, and 129 subjects (24.4％) have single TCM syndromes, 75 subjects (14.2％) have at least two TCM syndromes and 325 subjects (61.4％) have no TCM syndromes. Conclusion: Plasma glucose and blood pressure are associated and interacted with several physical indexes. TCM syndromes distribution was found no significant change among subjects with different plasma glucose and blood pressure.
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Objective To explore the application effect of self-developed strait jacket in mental patients.Methods A total of 200 mental patients meeting indications for protective restraint were selected from a tertiary first-class psychiatric hospital using convenience sampling,and were restrained using self-developed strait jackets,application effects and numbers of adverse events occurring during restraint were observed;patients' satisfaction with restraint tools was investigated as well.Results Cases of adverse events occurring during protective restraint were:3 patients developed dysaemia (1.50％),3 had self-injury (1.50％),4 were injured by others (2.00％),5 developed skin scratching (2.50％),7 threw off restraint by themselves (3.50％),13 presented violent and aggressive behaviors (6.50％),and no patient developed swelling of limbs.According to satisfaction survey,71.00％ of the patients demonstrated acceptance of this restraint tool,76.50％ felt comfortable,83.50％ held that this strait jacket could meet the needs of free activities,76.00％ felt safe,and satisfaction to body strait jacket came to 83.00％.Conclusion The manufacture of body strait jacket is simple and it is comfortable to wear,patient's compliance is high,and restraint effect is satisfactory;this body strait jacket reduces the incidence of adverse events,and improve patient's satisfaction to restraint tool.
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<p><b>OBJECTIVE</b>To detect the number of cells and the level of IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-γ and IL-17 cytokines in the peripheral blood of mice exposed to rocket kerosene by skin.</p><p><b>METHOD</b>ICR mice were randomly divided into the normal control group and RK experimental group (400 µl×1 group). RK undiluted fuel were applied directly to the dorsal skin of the mice. In control groups were treated with sesame oil (SO). the number of blood cells were detected by automatic blood cell counter and the level of IL-2, IL-4, IL-6, IL-10, TNF-alpha, IFN-γ and IL-17 cytokines in serum were detected by using flow cytometry and BD CBA Flex set kit.</p><p><b>RESULT</b>Compared with the normal group, WBC and LYM had a decreasing tendency 2 h and decreased significantly 6 h, 12 h and 1 d after RK exposure (P<0.05). They increased significantly 7 d after RK exposure (P<0.05). Compared with the normal group, the level of IL-6 increased significantly 2 h, 6 h, 12 h,1 d and 3 d (P<0.05). The level of TNF-α increased significantly 2h, 3d, 5d and 7d (P<0.05). The level of IL-10 increased significantly 2 h, 6 h, 3 d, 5 d and 7 d (P<0.05). The level of IFN-γ increased significantly 6 h and 3 d (P< 0.05). The level of IL-17 significantly increased 3 d, 5 d and 7d (P<0.05).</p><p><b>CONCLUSION</b>RK can change the number of immune cells, causing the immune cytokine changes in mice after RK cutaneous exposure.</p>
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Animals , Mice , Administration, Cutaneous , Blood Cell Count , Cytokines , Blood , Flow Cytometry , Kerosene , Toxicity , Mice, Inbred ICRABSTRACT
Objective To investigate the epidemiological characteristics of hand-foot-mouth disease. Methods A total of 589 children from Xianju county,Zhejiang province with hand-foot-mouth disease in 2013 were recruited in the study and the diagnosis went through clinical and laboratory confirmation. Attributes that were analyzed included gender,age,month of occurrence, regional distribution and clinical presentation. Results The incidence rate of hand-foot-mouth disease in Xianju county for the year was 102.72/100 000,with 12 severe cases but no death. There were clearly more boys than girls,with a male to female ratio of 1.29∶1,which was statistically significant(χ2=14.274,P<0.001). The vast majority of patients were 0-3 years old,representing 94.74% of the patients. The occurrences were concentrated in the period from April to August and November,with April as the high-incidence season. High incidence areas were the countryside and suburbs,making up 45.50%and 30.73%,respectively,of all cases. Most patients were in preschools or scattered home care environments,accounting for 51.10% and 40.92% ,respectively. Clinical presentation was characterized by fever and various kinds of vesicles or papules at the hand,foot, mouth or buttocks. Conclusion Most of hand-foot-mouth disease cases occur in younger children in areas with inadequate knowledge of hygiene,with seasonal variation.
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Objective To investigate the epidemiological characteristics of hand-foot-mouth disease. Methods A total of 589 children from Xianju county,Zhejiang province with hand-foot-mouth disease in 2013 were recruited in the study and the diagnosis went through clinical and laboratory confirmation. Attributes that were analyzed included gender,age,month of occurrence, regional distribution and clinical presentation. Results The incidence rate of hand-foot-mouth disease in Xianju county for the year was 102.72/100 000,with 12 severe cases but no death. There were clearly more boys than girls,with a male to female ratio of 1.29∶1,which was statistically significant(χ2=14.274,P<0.001). The vast majority of patients were 0-3 years old,representing 94.74% of the patients. The occurrences were concentrated in the period from April to August and November,with April as the high-incidence season. High incidence areas were the countryside and suburbs,making up 45.50%and 30.73%,respectively,of all cases. Most patients were in preschools or scattered home care environments,accounting for 51.10% and 40.92% ,respectively. Clinical presentation was characterized by fever and various kinds of vesicles or papules at the hand,foot, mouth or buttocks. Conclusion Most of hand-foot-mouth disease cases occur in younger children in areas with inadequate knowledge of hygiene,with seasonal variation.